abstract：:Patients with major depressive disorder (MDD) usually suffer from altered cognitive functions of episodic memory, working memory, mental processing speed and motor response. Diverse studies suggest that different antidepressant agents may improve cognitive functions in patients with MDD. The aim of this work is to stu...

journal_title：Journal of psychiatric research

authors： Herrera-Guzmán I,Gudayol-Ferré E,Herrera-Guzmán D,Guàrdia-Olmos J,Hinojosa-Calvo E,Herrera-Abarca JE

更新日期：2009-06-01 00:00:00

abstract：:Vitamin A and its derivatives, the retinoids, exert modulatory roles on central nervous system (CNS) function. However, the clinical use of vitamin A at moderate to high doses induces serious side effects, including dysfunctional brain metabolism and mood disorders. Then, we have investigated in this work the effects ...

journal_title：Journal of psychiatric research

authors： De Oliveira MR,Oliveira MW,Behr GA,Moreira JC

更新日期：2009-05-01 00:00:00

abstract：:Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, ...

journal_title：Journal of psychiatric research

authors： Nakao T,Nakagawa A,Nakatani E,Nabeyama M,Sanematsu H,Yoshiura T,Togao O,Tomita M,Masuda Y,Yoshioka K,Kuroki T,Kanba S

更新日期：2009-05-01 00:00:00

abstract：:The purpose of this study was to examine associations between abortion history and a wide range of anxiety (panic disorder, panic attacks, PTSD, Agoraphobia), mood (bipolar disorder, mania, major depression), and substance abuse disorders (alcohol and drug abuse and dependence) using a nationally representative US sam...

journal_title：Journal of psychiatric research

authors： Coleman PK,Coyle CT,Shuping M,Rue VM

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The requirement in classificatory systems that some impairment from attention-deficit/hyperactivity disorder (ADHD) symptoms starts before 7 years of age (age of onset of impairment criteria - AOC) has been harshly criticized. Although there is evidence that late-onset ADHD is a valid diagnosis, little is kno...

journal_title：Journal of psychiatric research

authors： Karam RG,Bau CH,Salgado CA,Kalil KL,Victor MM,Sousa NO,Vitola ES,Picon FA,Zeni GD,Rohde LA,Belmonte-de-Abreu P,Grevet EH

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE:In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI)...

journal_title：Journal of psychiatric research

authors： Serretti A,Calati R,Giegling I,Hartmann AM,Möller HJ,Rujescu D

更新日期：2009-02-01 00:00:00

abstract：:The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 and RIMS3 in the amygdala in schizophrenia. This study determined the levels of gene and protein expression for components of the active zo...

journal_title：Journal of psychiatric research

authors： Weidenhofer J,Scott RJ,Tooney PA

更新日期：2009-01-01 00:00:00

abstract：:Patients with obsessive-compulsive disorder (OCD) often display cognitions and/or behaviors that may well reflect the existence of "hyper-attachment" to different environmental elements, including their offspring, family members, divine entities, or even inanimate objects. Based on the fact that both OCD symptoms and ...

journal_title：Journal of psychiatric research

authors： Fontenelle LF,Soares ID,Miele F,Borges MC,Prazeres AM,Rangé BP,Moll J

更新日期：2009-01-01 00:00:00

abstract：:This study explored whether cerebral metabolic changes seen in treatment resistant and rapid cycling bipolar depression inpatients are also found in an outpatient sample not specifically selected for treatment resistance or rapid cycling. We assessed 15 depressed outpatients with bipolar disorder (six type I and nine ...

journal_title：Journal of psychiatric research

authors： Brooks JO 3rd,Wang PW,Bonner JC,Rosen AC,Hoblyn JC,Hill SJ,Ketter TA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:There is growing evidence that adolescence is a key period for neuronal maturation. Despite the high prevalence of marijuana use among adolescents and young adults in the United States and internationally, very little is known about its impact on the developing brain. Based on neuroimaging literature on norm...

journal_title：Journal of psychiatric research

authors： Ashtari M,Cervellione K,Cottone J,Ardekani BA,Sevy S,Kumra S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...

journal_title：Journal of psychiatric research

authors： Lamond AJ,Depp CA,Allison M,Langer R,Reichstadt J,Moore DJ,Golshan S,Ganiats TG,Jeste DV

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:While most of the second generation antipsychotic agents are associated with abnormal glucose metabolism, previous studies have shown that risperidone has relatively little effect upon blood glucose levels. This study aimed to explore the effect of risperidone on the glucose-regulating mechanism of patients ...

journal_title：Journal of psychiatric research

authors： Chen Q,Cai ZJ,Mao PX,Zhai YM,Mitchell PB,Tang YL

更新日期：2008-12-01 00:00:00

abstract：:The neuregulin-1 (NRG1) gene on chromosome 8p has been suggested as a potential susceptibility gene for schizophrenia. The exact way in which genetic variation in NRG1 might impact on this susceptibility for the disorder is a focus of current research. The present study aimed at investigating the possible relationship...

journal_title：Journal of psychiatric research

authors： Gruber O,Falkai P,Schneider-Axmann T,Schwab SG,Wagner M,Maier W

更新日期：2008-11-01 00:00:00

abstract：:Efficacy trials with antidepressant drugs often fail to show significant treatment effect even though efficacious treatments are investigated. This failure can, amongst other factors, be attributed to the lack of sensitivity of the statistical method as well as of the endpoints to pharmacological activity. For regulat...

journal_title：Journal of psychiatric research

authors： Santen G,Danhof M,Della Pasqua O

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Lower serotonin transporter (5-HTT) binding (BP(P)=f(P)B(avail)/K(D)) is reported during a major depressive episode (MDE) compared to healthy controls. Higher 5-HTT binding in the diencephalon has previously been associated with acute response to antidepressant treatment. We assessed baseline 5-HTT binding as...

journal_title：Journal of psychiatric research

authors： Miller JM,Oquendo MA,Ogden RT,Mann JJ,Parsey RV

更新日期：2008-10-01 00:00:00

abstract：:Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer's disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 patients with AD, 20 with mild...

journal_title：Journal of psychiatric research

authors： Thomann PA,Schläfer C,Seidl U,Santos VD,Essig M,Schröder J

更新日期：2008-10-01 00:00:00

abstract：:Altered corticosteroid milieu induces changes in hippocampal volume, neuronal structure, neurochemistry and cognitive function in humans and rodents. This in vivo magnetic resonance spectroscopy (1H MRS) and imaging (MRI) study investigated whether long-term alterations of the corticosteroid milieu cause: (i) metaboli...

journal_title：Journal of psychiatric research

authors： Schubert MI,Kalisch R,Sotiropoulos I,Catania C,Sousa N,Almeida OF,Auer DP

更新日期：2008-09-01 00:00:00

abstract：:Temperamental features are strongly associated with suicidal behaviors both in general population and clinical samples. In the present study we considered the association between personality traits, measured by Temperament and Character Inventory (TCI), and suicidal behavior. We analyzed five samples: a German control...

journal_title：Journal of psychiatric research

authors： Calati R,Giegling I,Rujescu D,Hartmann AM,Möller HJ,De Ronchi D,Serretti A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Frontolimbic dysfunction is observed in borderline personality disorder (BPD), with responses to emotional stimuli that are exaggerated in the amygdala and impaired in the anterior cingulate cortex (ACC). This pattern of altered function is consistent with animal models of stress responses and depression, whe...

journal_title：Journal of psychiatric research

authors： Minzenberg MJ,Fan J,New AS,Tang CY,Siever LJ

更新日期：2008-07-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [B...

journal_title：Journal of psychiatric research

authors： Colla M,Ende G,Alm B,Deuschle M,Heuser I,Kronenberg G

更新日期：2008-06-01 00:00:00

abstract：:This study tried to investigate the relationships between serum brain-derived neurotrophic factor (BDNF) protein levels and major depressive patients and discuss the effects of antidepressants on the serum BDNF protein levels. A total of 218 participants, including 111 patients with major depression (91 women) and 107...

journal_title：Journal of psychiatric research

authors： Huang TL,Lee CT,Liu YL

更新日期：2008-06-01 00:00:00

abstract：:Serotonergic dysfunction is present in mood disorders and suicide. Brainstem 5-HT1A somatodendritic autoreceptors regulate serotonin neuron firing but studies of autoreceptor binding in the dorsal raphe nucleus (DRN) in depressed suicides report conflicting results. We sought to determine: (1) the anatomical distribut...

journal_title：Journal of psychiatric research

authors： Boldrini M,Underwood MD,Mann JJ,Arango V

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Imaging and electroencephalographic studies have reported inter-hemispheric asymmetries in frontal cortical regions associated with depression. This study aimed at comparing motor corticospinal excitability assessed by methods of transcranial magnetic stimulation (TMS) between the right and left hemispheres ...

journal_title：Journal of psychiatric research

authors： Lefaucheur JP,Lucas B,Andraud F,Hogrel JY,Bellivier F,Del Cul A,Rousseva A,Leboyer M,Paillère-Martinot ML

更新日期：2008-04-01 00:00:00

abstract：:There are very few magnetic resonance spectroscopy studies in anorexia nervosa and none of them with young adolescent patients. We studied 12 anorexia nervosa (DSM-IV) patients aged 11-17 consecutively admitted to an Eating Disorders Unit. An evaluation with laboratory data, psychopathological scales, magnetic resonan...

journal_title：Journal of psychiatric research

authors： Castro-Fornieles J,Bargalló N,Lázaro L,Andrés S,Falcon C,Plana MT,Junqué C

更新日期：2007-12-01 00:00:00

abstract：:A number of lines of converging evidence suggest that brain-derived neurotrophic factor (BDNF) may play a role in the onset and treatment of bipolar disorder. We review pertinent data on BDNF from several different areas of preclinical and clinical investigation that suggest novel theoretical and treatment implication...

journal_title：Journal of psychiatric research

authors： Post RM

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVES:Clinical research projects gather large amounts of data. Typically, information is captured on paper source documents for later transcription to an electronic format, where responses can be checked, and errors, omissions, and inconsistencies can be resolved. These steps contribute delays, cost, and complexit...

journal_title：Journal of psychiatric research

authors： Cook IA,Balasubramani GK,Eng H,Friedman E,Young EA,Martin J,Nay WT,Ritz L,Rush AJ,Stegman D,Warden D,Trivedi MH,Wisniewski SR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Since the onset, prevalence, and course of specific psychopathological features rarely have been analyzed simultaneously from the start of dissimilar psychotic illnesses, we compared symptom-clusters in first-episode DSM-IV affective and non-affective psychotic disorders. METHODS:Subjects (N=377) from the M...

journal_title：Journal of psychiatric research

authors： Salvatore P,Khalsa HM,Hennen J,Tohen M,Yurgelun-Todd D,Casolari F,Depanfilis C,Maggini C,Baldessarini RJ

更新日期：2007-11-01 00:00:00

abstract：:In patients with bipolar disorder, recent brain imaging studies have reported cingulate cortex volume change. We performed a volumetric magnetic resonance imaging (MRI) study to assess the subregions of the cingulate gyrus; left anterior cingulate (LAC), left posterior cingulate (LPC), right anterior cingulate (RAC), ...

journal_title：Journal of psychiatric research

authors： Atmaca M,Ozdemir H,Cetinkaya S,Parmaksiz S,Belli H,Poyraz AK,Tezcan E,Ogur E

更新日期：2007-11-01 00:00:00

abstract：:It is well-known that increased lipid peroxidation and failure of antioxidant mechanisms leads to neuronal damage in schizophrenic patients. However, this neurodegenerative mechanism has not been studied in treatment refractory schizophrenics (TRS). Therefore, the main purpose of this study was to determine neuronal d...

journal_title：Journal of psychiatric research

authors： Medina-Hernández V,Ramos-Loyo J,Luquin S,Sánchez LF,García-Estrada J,Navarro-Ruiz A

更新日期：2007-10-01 00:00:00

abstract：:It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major ...

journal_title：Journal of psychiatric research

authors： Ruano D,Macedo A,Soares MJ,Valente J,Azevedo MH,Hutz MH,Gama CS,Lobato MI,Belmonte-de-Abreu P,Goodman AB,Pato C,Saraiva MJ,Heutink P,Palha JA

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Schizophrenia research has gained a new focus on identification and further characterization of neurocognitive deficits in the search for behavioural endophenotypes of this disorder. The objective of this study was to explore differential cortical processing during executive control in schizophrenia as asses...

journal_title：Journal of psychiatric research

authors： Neuhaus AH,Koehler S,Opgen-Rhein C,Urbanek C,Hahn E,Dettling M

更新日期：2007-10-01 00:00:00

abstract：UNLABELLED:A post hoc analysis of Young Mania Rating Scale (YMRS) item scores was conducted to identify symptoms that may predict impending relapse using prospectively collected data from a double-blind, randomized relapse prevention study of patients treated with olanzapine (N=200, 5-20 mg/d) versus lithium (N=201, 30...

journal_title：Journal of psychiatric research

authors： Houston JP,Lipkovich IA,Ahl J,Rotelli MD,Baker RW,Bowden CL

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Compulsive hoarding, found in many patients with obsessive-compulsive disorder (OCD), has been associated with poor response to serotonin reuptake inhibitor (SRI) medications in some reports. However, no prior study has quantitatively measured response to standardized pharmacotherapy in compulsive hoarders. W...

journal_title：Journal of psychiatric research

authors： Saxena S,Brody AL,Maidment KM,Baxter LR Jr

更新日期：2007-09-01 00:00:00

abstract：:Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) are common forms of dementia in the elderly. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic pla...

journal_title：Journal of psychiatric research

authors： Laske C,Stransky E,Leyhe T,Eschweiler GW,Maetzler W,Wittorf A,Soekadar S,Richartz E,Koehler N,Bartels M,Buchkremer G,Schott K

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:At effective doses, patients with major depressive disorder (MDD) treated with duloxetine have been found to experience significant symptom improvement as measured by HAMD(17) total score. In addition, duloxetine-treated patients have significantly higher remission and response rates compared with placebo. Th...

journal_title：Journal of psychiatric research

authors： Pritchett YL,Marciniak MD,Corey-Lisle PK,Berzon RA,Desaiah D,Detke MJ

更新日期：2007-04-01 00:00:00

abstract：:This study examines the correlates of a major depressive disorder and its treatment in the general population. The sample was composed of 6694 individuals aged between 18 and 96 years, representative of the general population of the states of California and New York (48 million inhabitants aged 18 years or older). The...

journal_title：Journal of psychiatric research

authors： Ohayon MM

更新日期：2007-04-01 00:00:00

abstract：:Previous reports suggest that massive hormonal changes that accompany the peripartum period may trigger perinatal depression. We investigated the relationship between magnitude of change and total level of estrogen and progesterone and grade of peripartal depression and depressive symptoms. One hundred and ninety two ...

journal_title：Journal of psychiatric research

authors： Klier CM,Muzik M,Dervic K,Mossaheb N,Benesch T,Ulm B,Zeller M

更新日期：2007-04-01 00:00:00

abstract：:Altered laterality of cortical activity, neuropsychological impairment and hypercortisolaemia have been shown in depression. The neural correlates of episodic memory in healthy subjects demonstrate hemispheric laterality but it is not known whether this is affected by depression and/or hypercortisolaemia. Twenty-seven...

journal_title：Journal of psychiatric research

authors： Alhaj HA,Massey AE,McAllister-Williams RH

更新日期：2007-04-01 00:00:00

abstract：:Individuals with bipolar disorder are at increased risk for suicide attempts and completion. Although anxiety may be a modifiable suicide risk factor among bipolar patients, anxiety disorder comorbidity has not been highlighted as critical in identification of high-risk individuals nor has its treatment been integrate...

journal_title：Journal of psychiatric research

authors： Simon NM,Zalta AK,Otto MW,Ostacher MJ,Fischmann D,Chow CW,Thompson EH,Stevens JC,Demopulos CM,Nierenberg AA,Pollack MH

更新日期：2007-04-01 00:00:00

abstract：:Given the high rates of cigarette smoking in schizophrenia in many published studies from around the world, we studied the relationship between smoking status and clinical characteristics in male Chinese schizophrenic inpatients. Two hundred seventy-nine schizophrenic inpatients were assessed using clinical data forms...

journal_title：Journal of psychiatric research

authors： Tang YL,George TP,Mao PX,Cai ZJ,Chen Q

更新日期：2007-01-01 00:00:00